Xinyu (Brian) Guo

郭昕育 Xinyu Guo

Researcher & developer

Los Angeles, CA

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Background

My research focuses on the intersection of genomics, statistical learning and deep learning, where I build tools that make sense of complex biological data and uncover patterns driving disease and therapy insights.

I'm especially drawn to new technology — from LLM-powered systems to computer vision pipelines. Every new algorithm is a chance to experiment and build something that bridges science and real-world impact.

Outside research I stay equally curious: usually behind a camera, chasing moments that say something about the people in them.

Research areas
Genomic foundation modelsCancer genomics & precision oncologyVariant-effect prediction (SNV, SV, fusion)Single-cell & spatial transcriptomicsSelf-supervised & contrastive learningGWAS / TWAS & statistical geneticsScientific AI agents & tool use
Technical
Python · R · C++ · SQL · Bash · TypeScriptPyTorch · PyTorch Geometric · JAXHugging Face · scikit-learn · CUDAGNN / GAT · state-space models (Mamba)RNA-seq · ChIP-seq · ATAC-seq · NGS somatic callingNextflow / WDL · DuckDB · Parquet · DockerAWS SageMaker · Bedrock · HealthOmicsMulti-GPU distributed training · HPC
Experience
  1. Summer 2026

    AI Research Scientist Intern

    Abbott Cancer Diagnostics — genomic AI & precision oncology

  2. 2022 — now

    Graduate Researcher

    University of Southern California — biological pathology AI/ML

  3. 2020 — 2022

    Graduate Researcher

    Johns Hopkins University — statistical genetics, multi-omics

  4. 2020

    Research Assistant

    Washington University in St. Louis — clinical informatics

Education
  1. 2022 — 2026

    Ph.D., Computational Biology & Bioinformatics

    University of Southern California · Viterbi Fellow

  2. 2020 — 2022

    M.S., Biostatistics

    Johns Hopkins University · Delta Omega Honor Society

  3. 2018 — 2020

    B.A., Mathematics & Computer Science

    Washington University in St. Louis · Cum Laude